Hubrecht Organoid Technology (The HUB)
The HUB is founded on the pioneering work of Prof. Dr. Hans Clevers who discovered methods to grow stem cell-derived human epithelial ‘mini-organs’ (organoids) from tissues of patients with various diseases including cancer and cystic fibrosis.
In cell culture, organoids stably maintain the genotype/phenotype of the patient’s diseased tissue, thereby representing an in vitro platform for preclinical drug discovery and validation and a tool for precision medicine. The HUB has established a ‘Living Biobank’, a rapidly-growing collection of well-characterized organoids derived from patient tissues. Through a combination of the proprietary Organoid Technology and the ‘Living Biobank’, the HUB provides access to a unique and robust platform that links patient-specific genetic and phenotypic information to preclinical and clinical drug-responsiveness.