Modular Tx

Modular Therapeutics is revolutionizing how we understand and harness gene expression in medicine, moving beyond the static, linear models that have shaped the field for decades.

Much like motion picture editing unlocked new narratives from discarded film strips, our RNA Dicing technology uncovers hidden layers of mRNA dynamics—distinct fragments with unique, previously unseen roles in cellular behavior.

Our approach is built on over a decade of groundbreaking research and development into RNA Dicing, combined with a cutting-edge computational platform that analyses and predicts isoform-specific gene expression dynamics. This synergy allows us to identify therapeutic opportunities overlooked by traditional models. By targeting specific mRNA isoforms, we provide precision tools for innovative drug design, tackling critical challenges such as drug resistance, limited efficacy, and the complex biology of previously undruggable pathologies.

In addition, our platform introduces an innovative concept in next-generation therapeutics: RNA Reprogramming. This breakthrough approach regulates the expression of mRNA variants from specific genes to produce desired protein isoforms. Unlike gene-editing methods, RNA Reprogramming acts transiently at the co- and posttranscriptional levels, avoiding genomic alterations while preserving the expression of beneficial protein isoforms.

Modular Therapeutics is transforming the narrative of gene expression, providing the tools and insights to reshape how we understand and treat disease. Our vision is to unravel the complexity of the RNA code across various pathologies, going beyond its role as a mere template for protein translation. By doing so, we aim to enable precision medicine that tackles some of the most pressing global health challenges.

Team
Yuval Malka
Willem-Jan Keune
Oran Oshpiz
Startup activities

Venture Challenge winter 24/25

Contact
Yuval Malka
yuvalmalka79@gmail.com